Apoptosis Reagents and Kits
Enzo Life Sciences NUCLEAR-ID Green chromatin condensation detection kit (1Kit)
The NUCLEAR-ID Green Chromatin Condensation Detection Kit detects nuclear condensation using a DNA intercalating dye that brightly stains the condensed chromatin of apoptotic cells, but only dimly stains the uncondensed chromatin of healthy living cells. Mechanism of Action The cell-permeable dye used in this application is an aromatic, planar cationic structure that inserts between stacked base pairs on the DNA duplex, providing an environmentally-dependent fluorescence enhancement of the dye molecules and large increases in fluorescence signal relative to the free dye in solution. Since the signal enhancement provides a proportional response, direct quantitation of DNA is possible. Further signal increase is observed upon DNA condensation during apoptosis.Applications: Flow Cytometry, Fluorescence microscopy, Fluorescent detection .
Abcam Z-Asp-CH2-DCB, caspase inhibitor, 10MG
MW 454.3 Da, Purity >98%. Irreversible, cell permeable broad-spectrum caspase inhibitor (IC₅₀ values are 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively). Inhibits hypoxia-induced apoptosis. Shows anti-ischemic effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam Lysosome/Mitochondria/Nuclear Staining Reagent - Cytopainter.
Lysosome/Mitochondria/Nuclear Staining Reagent - Cytopainter.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human SMAD2 knockout HeLa cell lysate.
Human SMAD2 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Bioss KD-Validated cleaved Caspase-9
Caspase 9 Primary Antibody Unconjugated Public Immunogen Range 90-350/416 Host Species Rabbit Target Species Human Mouse Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
Enzo Life Sciences Ac-WEHD-AMC (1mg)
Substrate for caspase-1, -4 and -5. Fluorogenic substrate for caspase-1 (Km=4µM), -4 (Km=31µM);and -5 (Km=15µM). This fluorogenic caspase-1 substrate with an optimal tetrapeptide sequence is cleaved 50-fold more efficiently than Ac-YVAD-AMC (ALX-260-024). Alternative name: Caspase 1 substrate (fluorogenic), Caspase 5 substrate (fluorogenic), Caspase 4 substrate (fluorogenic). Formula: C38H40N8O11. MW: 784.8. Purity: ≥98% (HPLC). Formulation: Lyophilized. Peptide content: 70-90%. Solubility: Soluble in DMSO (100mM, 75.5mg/ml). Dilute with distilled water or buffer. Long Term Storage: -20°C. Handling: Protect from light and moisture.
Abcam Lysosomal Staining Reagent - Green - Cytopainter.
Lysosomal Staining Reagent - Green - Cytopainter.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Annexin V-iFluor 555 Apoptosis Staining / Detection Reagent.
Annexin V-iFluor 555 Apoptosis Staining / Detection Reagent.
The product is subject to the following: Abcam Restricted Use Statement
Apexbio Technology LLC Annexin V-Cy5/DAPI Apoptosis Kit 50assays
Annexin V is a Ca2 -dependent phospholipid-binding protein that specifically binds to phosphatidylserine (PS) Normally PS is localized on the inner leaflet of the cell membrane lipid bilayer During the early stages of apoptosis PS translocates from the inner leaflet to the outer surface of the cell membrane exposing it to the extracellular environment Due to Annexin V s high affinity for PS fluorescently labeled Annexin V (Cy5) can be used as a fluorescent probe to detect apoptotic cells through flow cytometry or fluorescence microscopy with staining taking only 10-20 minutes DAPI specifically binds to double-stranded DNA emitting blue fluorescence but normally cannot permeate intact cell membranes However DAPI can enter late-stage apoptotic or dead cells and stain their nuclei Simultaneous staining with Annexin V-Cy5 and DAPI allows differentiation of cells at various stages of apoptosis and cell death
Medchemexpress LLC N-(Benzyloxycarbonyl)-D-homoserine | 41088-85-1 | MFCD12545887 | 253.25 | C12H15NO5 | 1 G
N-(Benzyloxycarbonyl)-D-homoserine is the D-enantiomer of homoserine bearing an N-carbobenzoxy (Cbz) protecting group. Supplied as a powder, it is used as a drug intermediate in small-molecule synthesis and can be employed in the preparation of antibody-drug conjugates (ADCs). Molecular formula C12H15NO5; molecular weight 253.25. Recommended storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Protected amino group enables selective synthetic transformations.
- Suitable for use as a drug intermediate in medicinal chemistry workflows.
- Powder form supports convenient handling and long-term storage.
- Defined molecular formula and mass aid analytical characterization.
- Established storage recommendations help preserve compound stability.
Abcam Human TK1 (Thymidine Kinase 1) knockout HEK-293T cell lysate.
Human TK1 (Thymidine Kinase 1) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
CPC Scientific Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO 0.5MG
Cell permeable inhibitor of caspase-1.ONE-LETTER SEQUENCE: Ac-AAVALLPAVLLALLAPYVAD-CHOMOLECULAR FORMULA: C97H160N20O24MOLECULAR WEIGHT:1990.46STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [201608-12-0], SYNONYMS: Cell-permeable Caspase-1 Inhibitor IRESEARCH AREA: ApoptosisREFERENCES: Y.-Z. Lin et al., J. Biol. Chem., 271, 5305 (1996); L.A. Reiter, Int. J. Pept. Protein Res., 43, 87 (1994); N.A. Thornberry et al., Biochemistry, 33, 3934 (1994)
Eurofins Discoverx KILR SKOV3 (Human) Cytotoxicity Assay Kit (cell pool)
The KILR SKOV3 (Human) Stable Cell Pool Cytotoxicity Assay utilizes the engineered stable target cell pool that is used to measure direct death mediated by immuno-oncology treatments via ADCC, CDC, and ADCP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Medchemexpress LLC Tasisulam | 519055-62-0 | 99.8% | 415.11 | 50 MG
Tasisulam is an anticancer agent that induces apoptosis via the intrinsic pathway, leading to cytochrome c release and caspase-dependent cell death. It inhibits mitotic progression and induces vascular normalization.
- Induces apoptosis via the intrinsic pathway
- Leads to cytochrome c release and caspase-dependent cell death
- Inhibits mitotic progression
- Induces vascular normalization
- Demonstrates antiproliferative response across tumor histologies
- Increases 4N DNA and G2-M accumulation
- Blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation
Eurofins Discoverx KILR U2OS (Human) PD-L2 Cytotoxicity Assay Kit (Clone)
The KILR U2OS Human PD-L2 Stable Cell Line Cytotoxicity Assay (U2OS) utilizes the stable, engineered U2OS-PD-L2 target cell line for quantifying effector-induced cell death. This assay enables measurement of immune cell-mediated killing through ADCC, ADCP and CDC. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.